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DPH1 / OVAC1 (C-Term), (AA 383-412) antibody

Details for Product No. ABIN951975
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Antigen
Epitope
C-Term, AA 383-412
(2)
Reactivity
Human
(3)
Host
Rabbit
(3)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(3), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN951975
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide between 383-412 amino acids from the C-terminal region of Human DPH1
Specificity This antibody recognizes Human DPH1 / OVAC1 (C-term).
Purification Affinity Chromatography on Protein A
Background Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2, MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM].
Alternate names: DPH1 homolog, DPH2L, DPH2L1, Diphthamide biosynthesis protein 1, Diphthamide biosynthesis protein 2 homolog-like 1, Ovarian cancer-associated gene 1 protein
Molecular Weight 48805 Da
Gene ID 1801
NCBI Accession NP_001374
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Bruening, Prowse, Schultz et al.: "Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells." in: Cancer research, Vol. 59, Issue 19, pp. 4973-83, 1999 (PubMed).

Salicioni, Xi, Vanderveer et al.: "Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor." in: Genomics, Vol. 69, Issue 1, pp. 54-62, 2000 (PubMed).

Chen, Behringer: "Cloning, structure, and expression of the mouse Ovca1 gene." in: Biochemical and biophysical research communications, Vol. 286, Issue 5, pp. 1019-26, 2001 (PubMed).

Cardoso, Leventer, Ward et al.: "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3." in: American journal of human genetics, Vol. 72, Issue 4, pp. 918-30, 2003 (PubMed).

Liu, Milne, Kuremsky et al.: "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2." in: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9487-97, 2004 (PubMed).

Hosts (3)
Reactivities (3)
Applications (3), (1)
Epitopes (2)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN951975
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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