DPH1 / OVAC1 (C-Term), (AA 383-412) antibody

Details for Product No. ABIN951975
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Antigen
Epitope
C-Term, AA 383-412
(2), (1)
Reactivity
Human
(3)
Host
Rabbit
(4)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(4)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN951975
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Immunogen KLH conjugated synthetic peptide between 383-412 amino acids from the C-terminal region of Human DPH1
Specificity This antibody recognizes Human DPH1 / OVAC1 (C-term).
Purification Affinity Chromatography on Protein A
Background Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2, MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM].
Alternate names: DPH1 homolog, DPH2L, DPH2L1, Diphthamide biosynthesis protein 1, Diphthamide biosynthesis protein 2 homolog-like 1, Ovarian cancer-associated gene 1 protein
Molecular Weight 48805 Da
Gene ID 1801
NCBI Accession NP_001374
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Bruening, Prowse, Schultz et al.: "Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells." in: Cancer research, Vol. 59, Issue 19, pp. 4973-83, 1999 (PubMed).

Salicioni, Xi, Vanderveer et al.: "Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor." in: Genomics, Vol. 69, Issue 1, pp. 54-62, 2000 (PubMed).

Chen, Behringer: "Cloning, structure, and expression of the mouse Ovca1 gene." in: Biochemical and biophysical research communications, Vol. 286, Issue 5, pp. 1019-26, 2001 (PubMed).

Cardoso, Leventer, Ward et al.: "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3." in: American journal of human genetics, Vol. 72, Issue 4, pp. 918-30, 2003 (PubMed).

Liu, Milne, Kuremsky et al.: "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2." in: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9487-97, 2004 (PubMed).

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