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DUOX2 antibody (Dual Oxidase 2) (AA 520-550)

Details for Product anti-DUOX2 Antibody No. ABIN951993, Supplier: Log in to see
Antigen
  • A430065P05Rik
  • LNOX2
  • NOXEF2
  • P138-TOX
  • TDH6
  • Thox2
  • THOX2
Epitope
AA 520-550, Middle Region
15
9
9
5
4
1
Reactivity
Human
26
11
9
9
9
Host
Rabbit
28
Clonality
Polyclonal
Conjugate
This DUOX2 antibody is un-conjugated
3
2
2
2
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
26
15
13
1
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 520-550 amino acids from the Central region of human DUOX2
Isotype Ig
Specificity This antibody recognizes Human Dual oxidase 2 (Center).
Purification Affinity Chromatography on Protein A
Alternative Name Dual Oxidase 2 (DUOX2 Antibody Abstract)
Background The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.Synonyms: LNOX2, Large NOX 2, Long NOX 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, NADPH thyroid oxidase 2, THOX2, Thyroid oxidase 2, p138 thyroid oxidase
Molecular Weight 175364 Da
Gene ID 50506
NCBI Accession NP_054799
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-DUOX2 antibody (Dual Oxidase 2) (AA 520-550) (ABIN951993) Flow cytometric analysis of CEM cells using Dual oxidase 2  Antibody  (right histogra...
Western Blotting (WB) image for anti-DUOX2 antibody (Dual Oxidase 2) (AA 520-550) (ABIN951993) Western blot analysis of Dual oxidase 2  Antibody  in CEM cell line lysates (35ug/lan...
Background publications Salmeen, Park, Meyer: "The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway." in: Oncogene, Vol. 29, Issue 31, pp. 4473-84, 2010

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010