Dynamitin antibody (Dynactin 2 (p50)) (AA 191-219)

Details for Product anti-DCTN2 Antibody No. ABIN952005, Supplier: Log in to see
Antigen
  • DCTN2
  • dctn2
  • dctn50
  • dynamitin
  • rbp50
  • CG8269
  • DMN
  • Dmel\\CG8269
  • P50
  • dDyn
  • dmn
  • dyna
  • l(2)k16109
  • l(2)k16218
  • p50
  • p50/Dmn
  • p50/dynamitin
  • 2310042E05Rik
  • C130077D06Rik
  • C87049
  • DCTN-50
  • GMP23-48K
  • RBP50
  • DCTN50
  • DYNAMITIN
  • zgc:63867
  • dynactin 2 (p50)
  • Dynamitin
  • dynactin 2
  • DCTN2
  • dctn2-b
  • Dmn
  • dctn2
  • Dctn2
  • dctn2-a
Alternatives
anti-Human Dynamitin antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 191-219, Middle Region
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Reactivity
Human
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This Dynamitin antibody is un-conjugated
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Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide between 191-219 amino acids from the Central region of Human Dynactin subunit 2. Genename: DCTN2
Isotype Ig
Specificity This antibody recognizes Human Dynactin subunit 2 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name Dynactin Subunit 2 (DCTN2 Antibody Abstract)
Background This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.Synonyms: 50 kDa dynein-associated polypeptide, DCTN2, DCTN50, Dynactin 2, Dynactin complex 50 kDa subunit, RBP50, p50 dynamitin
Molecular Weight 44231 Da
Gene ID 10540
NCBI Accession NP_006391
Pathways M Phase, Ribonucleoprotein Complex Subunit Organization
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Dynactin 2 (p50) (DCTN2) (AA 191-219), (Middle Region) antibody (ABIN952005) Formalin fixed and paraffin embedded human stomach tissue stained with  Dynactin subu...
Western Blotting (WB) image for anti-Dynactin 2 (p50) (DCTN2) (AA 191-219), (Middle Region) antibody (ABIN952005) Western blot analysis of DCTN2 (arrow) using Dynactin subunit 2 Antibody . 293 cell l...
Background publications Jacquot, Maidou-Peindara, Benichou: "Molecular and functional basis for the scaffolding role of the p50/dynamitin subunit of the microtubule-associated dynactin complex." in: The Journal of biological chemistry, Vol. 285, Issue 30, pp. 23019-31, 2010 (PubMed).

Inoue, Arasaki, Ueda, Aoki, Tagaya: "N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 13, Issue 8, pp. 905-14, 2008 (PubMed).

Maier, Godfrey, Echeverri, Cheong, Schroer: "Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure." in: Traffic (Copenhagen, Denmark), Vol. 9, Issue 4, pp. 481-91, 2008 (PubMed).

Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Camargo, Collura, Rain, Mizuguchi, Hermjakob, Kerrien, Bonnert, Whiting, Brandon: "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia." in: Molecular psychiatry, Vol. 12, Issue 1, pp. 74-86, 2006 (PubMed).

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