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FXYD5 antibody (Middle Region)

FXYD5 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN952009
  • Target See all FXYD5 Antibodies
    FXYD5 (FXYD Domain Containing Ion Transport Regulator 5 (FXYD5))
    Binding Specificity
    • 7
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 70-100, Middle Region
    Reactivity
    • 21
    • 2
    • 1
    • 1
    Human
    Host
    • 20
    • 1
    Rabbit
    Clonality
    • 21
    Polyclonal
    Conjugate
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    This FXYD5 antibody is un-conjugated
    Application
    • 20
    • 16
    • 15
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody recognizes Human Dysadherin / FXYD5 (Center).
    Purification
    Protein A column, followed by peptide affinity purification
    Immunogen
    KLH conjugated synthetic peptide between 70-100 amino acids from the Central region of Human Dysadherin / FXYD5
    Isotype
    Ig Fraction
    Top Product
    Discover our top product FXYD5 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    FXYD5 (FXYD Domain Containing Ion Transport Regulator 5 (FXYD5))
    Alternative Name
    Dysadherin / FXYD5 (FXYD5 Products)
    Synonyms
    FXYD5 antibody, DYSAD antibody, IWU1 antibody, KCT1 antibody, OIT2 antibody, PRO6241 antibody, RIC antibody, EF-8 antibody, Oit2 antibody, FXYD domain containing ion transport regulator 5 antibody, FXYD domain-containing ion transport regulator 5 antibody, FXYD5 antibody, Fxyd5 antibody
    Background
    This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu.].Synonyms: DYSAD, FXYD domain-containing ion transport regulator 5, IWU1
    Gene ID
    53827
    NCBI Accession
    NP_001158077
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