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EDEM3 antibody (ER Degradation Enhancer, Mannosidase alpha-Like 3) (C-Term)

Details for Product anti-EDEM3 Antibody No. ABIN952023, Supplier: Log in to see
Antigen
  • 2310050N11Rik
  • C1orf22
  • RGD1561496
Epitope
C-Term, AA 773-802
20
15
2
Reactivity
Human
25
2
2
Host
Rabbit
25
Clonality
Polyclonal
Conjugate
This EDEM3 antibody is un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
21
15
2
2
Supplier
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Immunogen KLH conjugated synthetic peptide between 773-802 amino acids from the C-terminal region of human EDEM3
Isotype Ig
Specificity This antibody recognizes Human EDEM3 (C-term).
Purification Affinity Chromatography on Protein A
Alternative Name EDEM3 (EDEM3 Antibody Abstract)
Background Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).Synonyms: C1orf22, ER degradation-enhancing alpha-mannosidase-like 3
Molecular Weight 104664 Da
Gene ID 80267
NCBI Accession NP_079467
Research Area Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-EDEM3 antibody (ER Degradation Enhancer, Mannosidase alpha-Like 3) (C-Term) (ABIN952023) Western blot analysis of EDEM3 Antibody (C-term) in A2058 cell line lysates (35ug/lan...
Background publications Hirao, Natsuka, Tamura, Wada, Morito, Natsuka, Romero, Sleno, Tremblay, Herscovics, Nagata, Hosokawa: "EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9650-8, 2006 (PubMed).

Mast, Diekman, Karaveg, Davis, Sifers, Moremen: "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins." in: Glycobiology, Vol. 15, Issue 4, pp. 421-36, 2005 (PubMed).

Olivari, Galli, Alanen, Ruddock, Molinari: "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation." in: The Journal of biological chemistry, Vol. 280, Issue 4, pp. 2424-8, 2005 (PubMed).

Sood, Bonner, Makalowska, Stephan, Robbins, Connors, Morgenbesser, Su, Faruque, Pinkett, Graham, Baxevanis, Klinger, Landes, Trent, Carpten: "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus." in: Genomics, Vol. 73, Issue 2, pp. 211-22, 2001 (PubMed).