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Endothelin 3 antibody (EDN3) (C-Term)

Details for Product anti-EDN3 Antibody No. ABIN952025, Supplier: Log in to see
Antigen
  • 114CH19
  • EDN3
  • et-3
  • ET-3
  • Et3
  • ET3
  • HSCR4
  • ls
  • PPET3
  • preproET-3
  • RGD1564825
  • tmgc48
  • WS4B
Epitope
C-Term, AA 175-205
22
15
8
6
3
3
2
1
1
Reactivity
Human
79
23
22
2
1
Host
Rabbit
68
12
Clonality
Polyclonal
Conjugate
This Endothelin 3 antibody is un-conjugated
5
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
51
35
15
11
4
3
2
2
1
Supplier
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Immunogen conjugated synthetic peptide between 175-205 amino acids from the C-terminal region of Human Endothelin-3. Genename: EDN3
Isotype Ig
Specificity This antibody recognizes Human Endothelin-3 (C-term).
Purification Affinity Chromatography on Protein A
Alternative Name Endothelin-3 (EDN3 Antibody Abstract)
Background The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.Synonyms: EDN3, ET-3, ET3, HSCR4, MGC15067, MGC61498, PPET3, Preproendothelin-3, WS4B
Molecular Weight 25454 Da
Gene ID 1908
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -80 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Endothelin 3 antibody (EDN3) (C-Term) (ABIN952025) Western blot analysis of Endothelin-3 Antibody (C-term) in NCI-H460 cell line lysates...
Background publications Darrah, McKone, OConnor, Rodgers, Genatossio, McNamara, Gibson, Stuart Elborn, Ennis, Gallagher, Kalsheker, Aitken, Wiese, Dunn, Smith, Pace, Londono, Goddard, Knowles, Drumm: "EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity." in: Physiological genomics, Vol. 41, Issue 1, pp. 71-7, 2010 (PubMed).

Sánchez-Mejías, Fernández, López-Alonso, Antiñolo, Borrego: "New roles of EDNRB and EDN3 in the pathogenesis of Hirschsprung disease." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 12, Issue 1, pp. 39-43, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).