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Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C) (N-Term), (AA 126-155) antibody

Details for Product No. ABIN952048
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Antigen
Synonyms eif3s8, fi37c04, zgc:66128, wu:fb34a08, wu:fi37c04, EIF3S8, EIF3CL, eif3-p110, LOC733086, eIF3c, eIF3-S8, AO090011000340, eIF3-p110, 110kDa, 3230401O13Rik, Eif3s8, NIPIL(A3), NipilA3, Xs, Xsl, EIF3C
Epitope
N-Term, AA 126-155
(8), (7), (6), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(21), (12), (2)
Host
Rabbit
(28), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(28), (18), (7), (6), (6), (1), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN952048
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Immunogen KLH conjugated synthetic peptide between 126-155 amino acids from the N-terminal region of human EIF3CL
Specificity This antibody reacts to EIF3CL.
Purification Affinity chromatography on Protein A
Alternative Name EIF3C / EIF3S8
Background Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Alternate names: Eukaryotic translation initiation factor 3 subunit 8, Eukaryotic translation initiation factor 3 subunit C, eIF3 p110
Gene ID 8663
NCBI Accession NP_001032897
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Sugiyama, Masuda, Shinoda et al.: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).

Damoc, Fraser, Zhou et al.: "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 7, pp. 1135-46, 2007 (PubMed).

Masutani, Sonenberg, Yokoyama et al.: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, 2007 (PubMed).

Zhou, Sandercock, Fraser et al.: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, 2008 (PubMed).

Imielinski, Baldassano, Griffiths et al.: "Common variants at five new loci associated with early-onset inflammatory bowel disease." in: Nature genetics, Vol. 41, Issue 12, pp. 1335-40, 2009 (PubMed).

Validation Images
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