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Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C) (AA 537-567), (Middle Region) antibody

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Synonyms eif3s8, fi37c04, zgc:66128, wu:fb34a08, wu:fi37c04, EIF3S8, EIF3CL, eif3-p110, LOC733086, eIF3c, eIF3-S8, AO090011000340, eIF3-p110, 110kDa, 3230401O13Rik, Eif3s8, NIPIL(A3), NipilA3, Xs, Xsl, EIF3C
AA 537-567, Middle Region
(15), (13), (11), (9), (9), (3), (2), (2), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(29), (24), (7)
(45), (1)
(3), (3), (3), (3), (3), (3)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(40), (27), (8), (7), (6), (3), (2), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 537-567 amino acids from the Central region of human EIF3C
Isotype Ig
Specificity This antibody reacts to EIF3C.
Cross-Reactivity (Details) Species reactivity (tested):Mouse.
Purification Affinity chromatography on Protein A
Alternative Name EIF3C / EIF3S8 (EIF3C Antibody Abstract)
Background Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.Synonyms: Eukaryotic translation initiation factor 3 subunit 8, Eukaryotic translation initiation factor 3 subunit C, eIF3 p110
Molecular Weight 105344 Da
Gene ID 8663
NCBI Accession NP_001032897
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C) (AA 537-567), (Middle Region) antibody (ABIN952049) EIF3C Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (35µ...
Background publications Imielinski, Baldassano, Griffiths et al.: "Common variants at five new loci associated with early-onset inflammatory bowel disease." in: Nature genetics, Vol. 41, Issue 12, pp. 1335-40, 2009 (PubMed).

Zhou, Sandercock, Fraser et al.: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, 2008 (PubMed).

Masutani, Sonenberg, Yokoyama et al.: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, 2007 (PubMed).

Damoc, Fraser, Zhou et al.: "Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 7, pp. 1135-46, 2007 (PubMed).

Sugiyama, Masuda, Shinoda et al.: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).

Catalog No. ABIN952049
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