EPOR antibody (Middle Region)

Catalog No. ABIN952118

Product Details anti-EPOR Antibody

Target: EPOR (Erythropoietin Receptor (EPOR))

Binding Specificity: AA 328-357, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPOR antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human Erythropoietin receptor (Center).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 328-357 amino acids from the Central region of Human Erythropoietin receptor Genename: EPOR

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for EPOR

Target: EPOR (Erythropoietin Receptor (EPOR))

Alternative Name: Erythropoietin Receptor (EPOR Products)

Synonyms: EPOR antibody, epor antibody, EPO-R antibody, erythropoietin receptor antibody, erythropoietin receptor L homeolog antibody, EPOR antibody, epor antibody, Epor antibody, epor.L antibody

Background: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.Synonyms: EPO-R, EPOR

Molecular Weight: 55065 Da

Gene ID: 2057

NCBI Accession: NP_000112

Pathways: JAK-STAT Signaling