MDS1 and EVI1 Complex Locus (MECOM) (AA 1-30), (N-Term) antibody

Details for Product No. ABIN952135, Supplier: Log in to see
Antigen
  • evi1
  • im:7140716
  • prdm3
  • EVI1
  • AML1-EVI-1
  • MDS1
  • MDS1-EVI1
  • PRDM3
  • D630039M04Rik
  • Evi-1
  • Evi1
  • Jbo
  • Mds
  • Mds1
  • Mds1-Evi1
  • Prdm3
  • Znfpr1b1
  • AML1
  • AMLCR1
  • CBFA2
  • EVI-1
  • PEBP2aB
  • MDS1 and EVI1 complex locus
  • runt-related transcription factor 1
  • mecom
  • MECOM
  • LOC100343228
  • Mecom
  • RUNX1
Epitope
N-Term, AA 1-30
28
17
16
15
9
5
5
4
4
3
3
2
2
2
1
1
1
1
1
Reactivity
Human
105
34
9
4
4
3
3
2
1
1
1
Host
Rabbit
71
31
15
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
6
6
6
6
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
104
65
11
5
3
2
1
1
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of Human EVI1. Genename: MECOM
Isotype Ig
Specificity This antibody recognizes Human EVI1 (N-term).
Purification Affinity Chromatography on Protein A
Alternative Name EVI1 (MECOM Antibody Abstract)
Background EVI1 functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.Synonyms: EVI-1, Ecotropic virus integration site 1 protein homolog, MDS1 and EVI1 complex locus protein EVI1, MECOM
Molecular Weight 118276 Da
Gene ID 2122
NCBI Accession NP_001098547
Research Area Chromatin and Nuclear Signaling, Chromatin Binding Proteins, Cell Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-MDS1 and EVI1 Complex Locus (MECOM) (AA 1-30), (N-Term) antibody (ABIN952135) Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane)....
Background publications Gómez-Benito, Conchillo, García, Vázquez, Maicas, Vicente, Cristobal, Marcotegui, García-Ortí, Bandrés, Calasanz, Alonso, Odero: "EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2." in: British journal of cancer, Vol. 103, Issue 8, pp. 1292-6, 2010 (PubMed).

Goyama, Kurokawa: "Evi-1 as a critical regulator of leukemic cells." in: International journal of hematology, Vol. 91, Issue 5, pp. 753-7, 2010 (PubMed).