Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2) (N-Term), (AA 20-50) antibody

Details for Product No. ABIN952152
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Antigen
Synonyms par3, PAR-3, PAR3, F730031A08, ASIP, Baz, PAR3alpha, PARD-3, PARD3A, SE2-5L16, SE2-5LT1, SE2-5T2
Epitope
N-Term, AA 20-50
(8), (7), (4), (2), (2), (1)
Reactivity
Human
(50), (29), (29), (29), (29), (29), (12)
Host
Rabbit
(53)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(24), (18), (12), (10), (8), (6), (2), (1)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN952152
357.50 $
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Immunogen KLH conjugated synthetic peptide between 20-50 amino acids from the N-terminal region of human F2RL2
Specificity This antibody recognizes Human F2RL2 (N-term).
Purification Affinity Chromatography on Protein A
Alternative Name F2RL2
Background Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.
Alternate names: Coagulation factor II receptor-like 2, PAR-3, PAR3, Proteinase-activated receptor 3, Thrombin receptor-like 2
Molecular Weight 42508 Da
Gene ID 2151
NCBI Accession NP_004092
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Van Laer, Huyghe, Hannula et al.: "A genome-wide association study for age-related hearing impairment in the Saami." in: European journal of human genetics : EJHG, Vol. 18, Issue 6, pp. 685-93, 2010 (PubMed).

Popović, Paskas, Zivković et al.: "Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors." in: Journal of thrombosis and thrombolysis, Vol. 30, Issue 2, pp. 164-71, 2010 (PubMed).

Wysoczynski, Liu, Kucia et al.: "Thrombin regulates the metastatic potential of human rhabdomyosarcoma cells: distinct role of PAR1 and PAR3 signaling." in: Molecular cancer research : MCR, Vol. 8, Issue 5, pp. 677-90, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

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