H2A Histone Family, Member Y2 (H2AFY2) (N-Term), (AA 14-43) antibody

Details for Product No. ABIN952667
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Antigen
Synonyms RGD1561371, MGC69037, MGC130768, macroh2a2, im:6898017, wu:fa14g05, zgc:114051, macroH2A2
Epitope
N-Term, AA 14-43
(8), (7), (4), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(23), (5), (3)
Host
Rabbit
(23)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), ELISA, Western Blotting (WB)
(23), (9), (8), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN952667
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Immunogen KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of Human H2AFY2 / MACROH2A2
Specificity This antibody recognizes Human and Mouse H2AFY2 / MACROH2A2 (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name H2AFY2 / MACROH2A2
Background Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Alternate names: Core histone macro-H2A.2, Histone macroH2A2, mH2A2
Molecular Weight 40058 Da
Gene ID 55506
NCBI Accession NP_061119
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Zhang, Poustovoitov, Ye et al.: "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA." in: Developmental cell, Vol. 8, Issue 1, pp. 19-30, 2004 (PubMed).

Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Sporn, Kustatscher, Hothorn et al.: "Histone macroH2A isoforms predict the risk of lung cancer recurrence." in: Oncogene, Vol. 28, Issue 38, pp. 3423-8, 2009 (PubMed).

Xu, Zheng, Isaacs et al.: "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2136-40, 2010 (PubMed).

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