Hepcidin antibody (Middle Region)

Catalog No. ABIN952718

Product Details anti-Hepcidin Antibody

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Binding Specificity: AA 24-54, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hepcidin antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human Hepcidin / HAMP (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 24~54 amino acids from the Central region of Human Hepcidin / HAMP

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Hepcidin

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Alternative Name: Hepcidin / HAMP (HAMP Products)

Synonyms: HEPC antibody, HFE2B antibody, LEAP1 antibody, PLTR antibody, Hepcidin antibody, Hamp1 antibody, Hepc antibody, Hepc1 antibody, HAMP antibody, hepcidin antibody, hamp1 antibody, hep1 antibody, hepcidin antimicrobial peptide antibody, hepcidin-like antibody, hepcidin-1 antibody, Ham percentage antibody, HAMP antibody, Hamp antibody, hamp antibody, LOC100135935 antibody, LOC106584587 antibody

Background: HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.Synonyms: HEPC, LEAP-1, LEAP1, Liver-expressed antimicrobial peptide, PLTR, Putative liver tumor regressor

Molecular Weight: 9408 Da

Gene ID: 57817

NCBI Accession: NP_066998

Pathways: Hormone Activity, Transition Metal Ion Homeostasis