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HOXB8 antibody (Homeobox B8) (C-Term)

Details for Product anti-HOXB8 Antibody No. ABIN952779, Supplier: Log in to see
Antigen
  • Hox2r1a
  • HOX2
  • HOX2D
  • Hox-2.4
  • homeo box B8
  • homeobox B8
  • homeobox protein Hox-B8-like
  • Hoxb8
  • HOXB8
  • LOC100627661
Epitope
C-Term, AA 214-243
23
17
9
8
5
3
3
2
1
1
Reactivity
Human
61
30
20
4
2
2
1
1
1
Host
Rabbit
61
6
Clonality
Polyclonal
Conjugate
This HOXB8 antibody is un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
52
37
13
3
1
1
Options
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Immunogen KLH conjugated synthetic peptide between 214-243 amino acids from the C-terminal region of human HOXB8
Isotype Ig
Specificity This antibody recognizes Human HOXB8 / HOX2D (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name HOXB8 / HOX2D (HOXB8 Antibody Abstract)
Background This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.Synonyms: Homeobox protein Hox-B8, Hox-2.4, Hox-2D
Molecular Weight 27574 Da
Gene ID 3218
NCBI Accession NP_076921
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-HOXB8 antibody (Homeobox B8) (C-Term) (ABIN952779) Western blot analysis of HOXB8 / HOX2D Antibody (C-term) in HL-60 cell line lysates (...
Background publications Greer, Capecchi: "Hoxb8 is required for normal grooming behavior in mice." in: Neuron, Vol. 33, Issue 1, pp. 23-34, 2002 (PubMed).

Kosaki, Kosaki, Suzuki, Yoshihashi, Takahashi, Sasaki, Tomita, McGinnis, Matsuo: "Complete mutation analysis panel of the 39 human HOX genes." in: Teratology, Vol. 65, Issue 2, pp. 50-62, 2002 (PubMed).

Knoepfler, Sykes, Pasillas, Kamps: "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation." in: Oncogene, Vol. 20, Issue 39, pp. 5440-8, 2001 (PubMed).

Fujino, Yamazaki, Largaespada, Jenkins, Copeland, Hirokawa, Nakamura: "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes." in: Experimental hematology, Vol. 29, Issue 7, pp. 856-63, 2001 (PubMed).

Vider, Zimber, Hirsch, Estlein, Chastre, Prevot, Gespach, Yaniv, Gazit: "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression." in: Biochemical and biophysical research communications, Vol. 232, Issue 3, pp. 742-8, 1997 (PubMed).