HYAL2 antibody (Middle Region)

Catalog No. ABIN952808

Product Details anti-HYAL2 Antibody

Target: HYAL2 (Hyaluronidase-2 (HYAL2))

Binding Specificity: AA 127-157, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HYAL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human HYAL2 / Hyaluronidase-2 (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 127-157 amino acids from the Central region of Human HYAL2 / Hyaluronidase-2.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HYAL2

Target: HYAL2 (Hyaluronidase-2 (HYAL2))

Alternative Name: HYAL2 / Hyaluronidase-2 (HYAL2 Products)

Background: This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.Synonyms: Hyal-2, Hyaluronoglucosaminidase-2, LUCA2, Lung carcinoma protein 2

Molecular Weight: 53860 Da

Gene ID: 8692

NCBI Accession: NP_003764

Pathways: Transition Metal Ion Homeostasis, Glycosaminoglycan Metabolic Process