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IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788)

Details for Product anti-IL12RB2 Antibody No. ABIN952881, Supplier: Log in to see
Antigen
  • IL12RB2
  • A930027I18Rik
  • IL-12RB2
  • Ifnm
  • interleukin 12 receptor, beta 2
  • IL12RB2
  • Il12rb2
Alternatives
anti-Human IL12RB2 antibody for Western Blotting
Epitope
AA 759-788, C-Term
15
10
10
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3
2
2
1
1
1
1
1
1
Reactivity
Human
75
40
19
1
1
Host
Rabbit
66
22
Clonality
Polyclonal
Conjugate
This IL12RB2 antibody is un-conjugated
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6
6
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
58
39
28
27
13
7
4
4
4
1
1
Options
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 759-788aa) of human IL12RB2.
Isotype Ig
Specificity This antibody detects human IL12RB2 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a protein A column; followed by peptide affinity purification.
Alternative Name IL12RB2 (IL12RB2 Antibody Abstract)
Background The protein encoded by the IL12RB2 gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.Synonyms: IL-12 receptor beta-2, IL-12R-beta-2, Interleukin-12 receptor beta-2 chain
Gene ID 3595
NCBI Accession NP_001550
Research Area Cancer, Cytokines, Innate Immunity
Pathways JAK-STAT Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788) (ABIN952881) Flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788) (ABIN952881) Immunohistochemistry analysis in human tonsils tissue (formalin-fixed, paraffin-embed...
Western Blotting (WB) image for anti-IL12RB2 antibody (Interleukin 12 Receptor, beta 2) (AA 759-788) (ABIN952881) Western blot analysis in MDA-MB435 cell line lysates (35ug/lane) using IL12RB2  Antib...
Background publications Liu, Invernizzi, Lu, Kosoy, Lu, Bianchi, Podda, Xu, Xie, Macciardi, Selmi, Lupoli, Shigeta, Ransom, Lleo, Lee, Mason, Myers, Peltekian, Ghent, Bernuzzi, Zuin, Rosina, Borghesio, Floreani et al.: "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis...." in: Nature genetics, Vol. 42, Issue 8, pp. 658-60, 2010 (PubMed).

Mizuki, Meguro, Ota, Ohno, Shiota, Kawagoe, Ito, Kera, Okada, Yatsu, Song, Lee, Kitaichi, Namba, Horie, Takeno, Sugita, Mochizuki, Bahram, Ishigatsubo, Inoko: "Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci." in: Nature genetics, Vol. 42, Issue 8, pp. 703-6, 2010 (PubMed).

Remmers, Cosan, Kirino, Ombrello, Abaci, Satorius, Le, Yang, Korman, Cakiris, Aglar, Emrence, Azakli, Ustek, Tugal-Tutkun, Akman-Demir, Chen, Amos, Dizon, Kose, Azizlerli, Erer, Brand, Kaklamani, Kaklamanis, Ben-Chetrit, Stanford, Fortune, Ghabra, Ollier,: "Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease." in: Nature genetics, Vol. 42, Issue 8, pp. 698-702, 2010 (PubMed).