Integrin beta 7 antibody (C-Term)

Catalog No. ABIN952915

Product Details anti-Integrin beta 7 Antibody

Target: Integrin beta 7 (ITGB7)

Binding Specificity: AA 736-765, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin beta 7 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human Integrin beta-7 (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 736-765 amino acids from the C-terminal region of Human Integrin beta-7

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Alternative Name: Integrin beta-7 (ITGB7 Products)

Synonyms: Ly69 antibody, integrin beta 7 antibody, integrin subunit beta 7 antibody, integrin, beta 7 antibody, Itgb7 antibody, ITGB7 antibody

Background: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.Synonyms: ITGB7, Integrin alpha 4 beta 7, Integrin beta-P, LPAM-1, LPAM1, M290 IEL antigen

Molecular Weight: 86903 Da

Gene ID: 3695

NCBI Accession: NP_000880

Pathways: Integrin Complex