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IRF9 antibody (Interferon Regulatory Factor 9) (N-Term)

Details for Product anti-IRF9 Antibody No. ABIN952952, Supplier: Login to see New
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N-Term, AA 82-112
(13), (11), (9), (6), (5), (3), (3), (3), (2), (1), (1), (1)
Human, Mouse (Murine)
(57), (21), (5), (1), (1), (1), (1)
(52), (13), (3)
This IRF9 antibody is un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(50), (25), (24), (17), (11), (11), (10), (4), (2)
Pubmed 4 references available
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Quantity 0.4 mL
Shipping to United States ( )
Immunogen KLH conjugated synthetic peptide between 82-112 amino acids from the N-terminal region of Human IRF9 / ISGF3G
Specificity This antibody recognizes Human and Mouse IRF9 / ISGF3G (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name IRF9 / ISGF3G (IRF9 Antibody Abstract)
Background IRF9 is a transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Alternate names: IFN-alpha-responsive transcription factor subunit, IRF-9, ISGF-3 gamma, ISGF3 p48, Interferon regulatory factor 9, Interferon-stimulated gene factor 3 gamma, Transcriptional regulator ISGF3 subunit gamma
Molecular Weight 43696 Da
Gene ID 10379
NCBI Accession NP_006075
Pathways JAK-STAT Signaling, Interferon-gamma Pathway
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Maiwald, Schneider, Busch et al.: "Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon α-induced early antiviral signalling." in: The FEBS journal, Vol. 277, Issue 22, pp. 4741-54, 2010 (PubMed).

Schuurhof, Bont, Siezen et al.: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, 2010 (PubMed).

Watanabe, Asano, Fichtner-Feigl et al.: "NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway." in: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1645-62, 2010 (PubMed).

Mosbruger, Duggal, Goedert et al.: "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus." in: The Journal of infectious diseases, Vol. 201, Issue 9, pp. 1371-80, 2010 (PubMed).

Catalog No. ABIN952952

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