Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 1 (Kcnd1) (N-Term), (AA 117-147) antibody

Details for Product No. ABIN952999
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Antigen
Synonyms 1110037K09Rik, Kca2-1, Kv4.1, Shal, mShal1, KV4.1
Epitope
N-Term, AA 117-147
(8), (7), (4), (1), (1)
Reactivity
Human
(39), (25), (15), (12), (12), (12)
Host
Rabbit
(39), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(31), (21), (10), (4), (3), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN952999
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Immunogen KLH conjugated synthetic peptide between 117-147 amino acids from the N-terminal region of human KCND1
Specificity This antibody recognizes Human KCND1 (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name KCND1
Background Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.
Alternate names: Potassium voltage-gated channel subfamily D member 1, Voltage-gated potassium channel subunit Kv4.1
Molecular Weight 71330 Da
Gene ID 3750
NCBI Accession NP_004970
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Gutman, Chandy, Grissmer et al.: "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 473-508, 2005 (PubMed).

Jang, Choi, Hong et al.: "Silencing of Kv4.1 potassium channels inhibits cell proliferation of tumorigenic human mammary epithelial cells." in: Biochemical and biophysical research communications, Vol. 384, Issue 2, pp. 180-6, 2009 (PubMed).

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