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Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 2 (KIR3DL2) (AA 53-82), (N-Term) antibody

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Synonyms CD158K, NKAT-4, NKAT4, NKAT4B, p140
N-Term, AA 53-82
(6), (4), (2), (2)
(14), (1), (1)
(13), (1)
(2), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
(8), (5), (4), (2), (2), (2), (1)
Pubmed 2 references available
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Quantity 0.4 mL
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Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide between 53~82 amino acids from the N-terminal region of human KIR3DL2
Isotype Ig
Specificity This antibody recognizes Human KIR3DL2 (N-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name KIR3DL2 (KIR3DL2 Antibody Abstract)
Background Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.Synonyms: CD158 antigen-like family member K, CD158K, CD_antigen=CD158k, Flags: Precursor, Killer cell immunoglobulin-like receptor 3DL2, MHC class I NK cell receptor, NKAT-4, NKAT4, Natural killer-associated transcript 4, p70 NK receptor CL-5, p70 natural killer cell receptor clone CL-5
Molecular Weight 50230 Da
Gene ID 3812
NCBI Accession NP_006728
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 2 (KIR3DL2) (AA 53-82), (N-Term) antibody (ABIN953082) Flow cytometric analysis of HL-60 cells usng KIR3DL2 Antibody (N-term) Cat.-No AP5237...
Western Blotting (WB) image for anti-Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 2 (KIR3DL2) (AA 53-82), (N-Term) antibody (ABIN953082) Western blot analysis of KIR3DL2 Antibody (N-term) in HL-60 cell line lysates (35ug/l...
Background publications Pende, Biassoni, Cantoni et al.: "The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer." in: The Journal of experimental medicine, Vol. 184, Issue 2, pp. 505-18, 1996 (PubMed).

Döhring, Samaridis, Colonna: "Alternatively spliced forms of human killer inhibitory receptors." in: Immunogenetics, Vol. 44, Issue 3, pp. 227-30, 1996 (PubMed).

Catalog No. ABIN953082
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