Kin of IRRE Like 3 (Drosophila) (KIRREL3) (C-Term), (AA 596-626) antibody

Details for Product No. ABIN953085
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Antigen
Epitope
C-Term, AA 596-626
(1), (1), (1), (1)
Reactivity
Human
(20), (20), (20), (17), (1)
Host
Rabbit
(20), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(15), (14), (8), (4), (3), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN953085
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Immunogen KLH conjugated synthetic peptide between 596~626 amino acids from the C-terminal region of Human KIRREL3
Specificity This antibody recognizes Human KIRREL3 (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name KIRREL3
Background KIRREL3 is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in this gene are associated with mental retardation autosomal dominant type 4 (MRD4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternate names: KIAA1867, KIRREL3, Kin of IRRE-like protein 3, Kin of irregular chiasm-like protein 3, NEPH2, Nephrin-like 2
Molecular Weight 85255 Da
Gene ID 84623
NCBI Accession NP_001155179
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Sellin, Huber, Gerke et al.: "NEPH1 defines a novel family of podocin interacting proteins." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 17, Issue 1, pp. 115-7, 2003 (PubMed).

Melzer, Perry, Hernandez et al.: "A genome-wide association study identifies protein quantitative trait loci (pQTLs)." in: PLoS genetics, Vol. 4, Issue 5, pp. e1000072, 2008 (PubMed).

Anney, Lasky-Su, ODúshláine et al.: "Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 147B, Issue 8, pp. 1369-78, 2008 (PubMed).

Bhalla, Luo, Buchan et al.: "Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability." in: American journal of human genetics, Vol. 83, Issue 6, pp. 703-13, 2008 (PubMed).

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