anti-K-RAS antibody (GTPase Kras) (C-Term)

Details for Product anti-GTPase Kras Antibody No. ABIN953110
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Antigen
Epitope
C-Term, AA 145-174
(35), (13), (13), (12), (12), (7), (6), (6), (6), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(188), (35), (33), (17), (2), (2), (1), (1)
Host
Rabbit
(154), (55), (1)
Clonality
Polyclonal
Conjugate
This K-RAS antibody is un-conjugated
(13), (12), (12), (8), (8), (8), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
(161), (98), (59), (29), (24), (21), (20), (18), (14), (14), (12), (5), (4), (1)
Pubmed 3 references available
Quantity 0.4 mL
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Immunogen KLH conjugated synthetic peptide between 145-174 amino acids from the C-terminal region of Human KRAS
Specificity This antibody recognizes Mouse KRAS (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name KRAS
Background This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
Alternate names: GTPase KRas, K-Ras 2, KRAS2, Ki-Ras, RASK2, c-K-ras, c-Ki-ras
Gene ID 3845
NCBI Accession NP_004976
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Bruckman, Schönleben, Qiu et al.: "Mutational analyses of the BRAF, KRAS, and PIK3CA genes in oral squamous cell carcinoma." in: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Vol. 110, Issue 5, pp. 632-7, 2010 (PubMed).

Wong, Tsang, Deavers et al.: "BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas." in: The American journal of pathology, Vol. 177, Issue 4, pp. 1611-7, 2010 (PubMed).

Irahara, Baba, Nosho et al.: "NRAS mutations are rare in colorectal cancer." in: Diagnostic molecular pathology : the American journal of surgical pathology, part B, Vol. 19, Issue 3, pp. 157-63, 2010 (PubMed).

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Catalog No. ABIN953110
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