GTPase Kras (C-Term), (AA 157-186) antibody

Details for Product No. ABIN953111
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Antigen
Synonyms
C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2, AI929937, K-ras, Ki-ras, Kras-2, Kras2, p21B, ras, p21, c-Ki-ras, zgc:85725, wu:fa04e08, wu:fc14b12, wu:fc23g10 ... show more
C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2, AI929937, K-ras, Ki-ras, Kras-2, Kras2, p21B, ras, p21, c-Ki-ras, zgc:85725, wu:fa04e08, wu:fc14b12, wu:fc23g10, wu:fj89d12 show less
Epitope
C-Term, AA 157-186
(4), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(67), (37), (36), (13), (2), (1), (1), (1)
Host
Rabbit
(62), (14), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(53), (27), (20), (19), (11), (4), (3), (2), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN953111
Quantity 0.4 mL
Price
335.50 $   Plus shipping costs $45.00
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Immunogen KLH conjugated synthetic peptide between 157-186 amino acids from the C-terminal region of human KRAS
Specificity This antibody recognizes Human and Mouse KRAS (C-term).
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name KRAS
Background This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
Alternate names: GTPase KRas, K-Ras 2, KRAS2, Ki-Ras, RASK2, c-K-ras, c-Ki-ras
Molecular Weight 21656 Da
Gene ID 3845
NCBI Accession NP_004976
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Carotenuto, Roma, Rachiglio et al.: "Detection of KRAS mutations in colorectal carcinoma patients with an integrated PCR/sequencing and real-time PCR approach." in: Pharmacogenomics, Vol. 11, Issue 8, pp. 1169-79, 2010 (PubMed).

Irahara, Baba, Nosho et al.: "NRAS mutations are rare in colorectal cancer." in: Diagnostic molecular pathology : the American journal of surgical pathology, part B, Vol. 19, Issue 3, pp. 157-63, 2010 (PubMed).

Wong, Tsang, Deavers et al.: "BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas." in: The American journal of pathology, Vol. 177, Issue 4, pp. 1611-7, 2010 (PubMed).

Leventopoulos, Denayer, Makrythanasis et al.: "Noonan syndrome and systemic lupus erythematosus in a patient with a novel KRAS mutation." in: Clinical and experimental rheumatology, Vol. 28, Issue 4, pp. 556-7, 2010 (PubMed).

Bruckman, Schönleben, Qiu et al.: "Mutational analyses of the BRAF, KRAS, and PIK3CA genes in oral squamous cell carcinoma." in: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Vol. 110, Issue 5, pp. 632-7, 2010 (PubMed).

Hosts (62), (14), (1)
Reactivities (67), (37), (36), (13), (2), (1), (1), (1)
Applications (53), (27), (20), (19), (11), (4), (3), (2), (2), (1), (1)
Conjugates (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (4), (3), (2), (2), (1), (1), (1), (1)
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