anti-K-RAS antibody (GTPase Kras) (C-Term)

Details for Product anti-GTPase Kras Antibody No. ABIN953111
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C-Term, AA 157-186
(33), (12), (11), (11), (7), (6), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(158), (47), (46), (2), (2), (1), (1), (1)
(139), (24), (1)
This K-RAS antibody is un-conjugated
(13), (12), (12), (8), (8), (8), (2), (2), (2), (2), (2), (2), (2), (2)
ELISA, Western Blotting (WB)
(123), (79), (59), (21), (20), (18), (18), (13), (12), (10), (5), (2)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Discontinued
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen KLH conjugated synthetic peptide between 157-186 amino acids from the C-terminal region of human KRAS
Specificity This antibody recognizes Human and Mouse KRAS (C-term).
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name KRAS
Background This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
Alternate names: GTPase KRas, K-Ras 2, KRAS2, Ki-Ras, RASK2, c-K-ras, c-Ki-ras
Molecular Weight 21656 Da
Gene ID 3845
NCBI Accession NP_004976
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Bruckman, Schönleben, Qiu et al.: "Mutational analyses of the BRAF, KRAS, and PIK3CA genes in oral squamous cell carcinoma." in: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Vol. 110, Issue 5, pp. 632-7, 2010 (PubMed).

Leventopoulos, Denayer, Makrythanasis et al.: "Noonan syndrome and systemic lupus erythematosus in a patient with a novel KRAS mutation." in: Clinical and experimental rheumatology, Vol. 28, Issue 4, pp. 556-7, 2010 (PubMed).

Wong, Tsang, Deavers et al.: "BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas." in: The American journal of pathology, Vol. 177, Issue 4, pp. 1611-7, 2010 (PubMed).

Irahara, Baba, Nosho et al.: "NRAS mutations are rare in colorectal cancer." in: Diagnostic molecular pathology : the American journal of surgical pathology, part B, Vol. 19, Issue 3, pp. 157-63, 2010 (PubMed).

Carotenuto, Roma, Rachiglio et al.: "Detection of KRAS mutations in colorectal carcinoma patients with an integrated PCR/sequencing and real-time PCR approach." in: Pharmacogenomics, Vol. 11, Issue 8, pp. 1169-79, 2010 (PubMed).

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Catalog No. ABIN953111
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