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MEF2D antibody (Myocyte Enhancer Factor 2D) (N-Term)

Details for Product anti-MEF2D Antibody No. ABIN953381, Supplier: Log in to see
Antigen
  • sl1
  • sl-1
  • XMEF2D
  • MGC145245
  • C80750
Epitope
N-Term, AA 115-144
19
18
15
15
14
14
10
7
6
4
4
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
116
51
50
2
2
2
1
Host
Rabbit
96
20
Clonality
Polyclonal
Conjugate
This MEF2D antibody is un-conjugated
7
7
7
4
4
4
3
3
3
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
76
44
33
15
12
6
4
Supplier
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Immunogen KLH conjugated synthetic peptide between 115-144 amino acids from the N-terminal region of human MEF2D
Isotype Ig
Specificity This antibody reacts to MEF2D.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name MEF2D (MEF2D Antibody Abstract)
Background Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor-and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity).Synonyms: Myocyte-specific enhancer factor 2D
Molecular Weight 55938 Da
Gene ID 4209
NCBI Accession NP_005911
Research Area Cardiovascular, Hypertrophy, Cardiogenesis, Transcription Factors, Neurogenesis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-MEF2D antibody (Myocyte Enhancer Factor 2D) (N-Term) (ABIN953381) MEF2D Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35µg/lane...
Background publications Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Aude-Garcia, Collin-Faure, Bausinger et al.: "Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression." in: The Biochemical journal, Vol. 430, Issue 2, pp. 237-44, 2010 (PubMed).

Czubryt, Lamoureux, Ramjiawan et al.: "Regulation of cardiomyocyte Glut4 expression by ZAC1." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 16942-50, 2010 (PubMed).