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MGAT3 antibody (Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase) (C-Term)

Details for Product anti-MGAT3 Antibody No. ABIN953408, Supplier: Log in to see
Antigen
  • 1110038J12Rik
  • AI848272
  • GnT-III
  • GNT-III
  • GNT3
  • mgat3
  • MGAT3
  • zgc:112067
Epitope
C-Term, AA 425-454
19
17
15
2
2
2
2
2
2
1
1
1
1
Reactivity
Human
59
11
7
Host
Rabbit
55
4
Clonality
Polyclonal
Conjugate
This MGAT3 antibody is un-conjugated
4
4
4
4
4
4
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
51
35
21
7
4
3
2
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 425-454 amino acids from the C-terminal region of human MGAT3
Isotype Ig
Specificity This antibody reacts to MGAT3.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name MGAT3 (MGAT3 Antibody Abstract)
Background There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.Synonyms: 4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, Beta-1, GGNT3
Molecular Weight 61313 Da
Gene ID 4248
NCBI Accession NP_001091740
Research Area Organelles
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-MGAT3 antibody (Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase) (C-Term) (ABIN953408) MGAT3 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35µg/...
Product cited in: Benson, Grobarova, Richter, Fiserova: "Glycosylation regulates NK cell-mediated effector function through PI3K pathway." in: International immunology, Vol. 22, Issue 3, pp. 167-77, 2010 (PubMed).

Background publications Akasaka-Manya, Manya, Sakurai, Wojczyk, Kozutsumi, Saito, Taniguchi, Murayama, Spitalnik, Endo: "Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease." in: Glycobiology, Vol. 20, Issue 1, pp. 99-106, 2009 (PubMed).

Pinho, Reis, Paredes, Magalhães, Ferreira, Figueiredo, Xiaogang, Carneiro, Gärtner, Seruca: "The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin." in: Human molecular genetics, Vol. 18, Issue 14, pp. 2599-608, 2009 (PubMed).

Sato, Isaji, Tajiri, Yoshida-Yamamoto, Yoshinaka, Somehara, Fukuda, Wada, Gu: "An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 11873-81, 2009 (PubMed).

Fiala, Liu, Espinosa-Jeffrey, Rosenthal, Bernard, Ringman, Sayre, Zhang, Zaghi, Dejbakhsh, Chiang, Hui, Mahanian, Baghaee, Hong, Cashman: "Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 31, pp. 12849-54, 2007 (PubMed).