NLR Family, Pyrin Domain Containing 11 (NLRP11) (AA 467-497), (Middle Region) antibody

Details for Product No. ABIN953598
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Antigen
Synonyms CLR19.6, NALP11, NOD17, PAN10, PYPAF6, PYPAF7
Epitope
AA 467-497, Middle Region
(8), (2), (2), (1)
Reactivity
Human
(14)
Host
Rabbit
(12), (2)
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Flow Cytometry (FACS)
(11), (10), (5), (5), (2)
Pubmed 2 references available
Catalog no. ABIN953598
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Discontinued
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Immunogen KLH conjugated synthetic peptide between 467~497 amino acids from the Central region of Human NALP11
Specificity This antibody recognizes Human NALP11 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name NALP11
Background NAL11 are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C- terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C- terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NAL11 are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
Alternate names: LRR and PYD domains-containing protein 11, NACHT, NLRP11, NOD17, Nucleotide-binding oligomerization domain protein 17, PYPAF6, PYRIN-containing APAF1-like protein 6
Molecular Weight 117779 Da
Gene ID 204801
NCBI Accession NP_659444
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Baranzini, Wang, Gibson et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis...." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, 2009 (PubMed).

Enjuanes, Benavente, Bosch et al.: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).

Hosts (12), (2)
Reactivities (14)
Applications (11), (10), (5), (5), (2)
Epitopes (8), (2), (2), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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