NAL11 are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C- terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C- terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NAL11 are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
Alternate names: LRR and PYD domains-containing protein 11, NACHT, NLRP11, NOD17, Nucleotide-binding oligomerization domain protein 17, PYPAF6, PYRIN-containing APAF1-like protein 6