NDUF3 (N-Term), (AA 12-40) antibody

Details for Product No. ABIN953627
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Antigen
Epitope
N-Term, AA 12-40
Reactivity
Human, Mouse (Murine)
Host
Rabbit
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 3 references available
Quantity 0.4 mL
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Catalog No. ABIN953627
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Immunogen KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human NDUF3
Isotype Ig
Specificity This antibody recognizes Human and Mouse NDUF3 (N-term).
Purification Protein A column, followed by peptide affinity purification
Background This gene encodes a mitochondrial complex I assembly protein that interacts with complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency, a fatal neonatal disorder of the oxidative phosphorylation system. Alternatively spliced transcript variants encoding different isoforms have been identified.Synonyms: C3orf60, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3, NDUFAF3
Molecular Weight 20350 Da
Gene ID 25915
NCBI Accession NP_951032
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Simpson, Wellenreuther, Poustka et al.: "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing." in: EMBO reports, Vol. 1, Issue 3, pp. 287-92, 2001 (PubMed).

Hammami-Hamza, Doussau, Allemand et al.: "2P1, a novel male mouse cDNA specifically expressed during meiosis." in: The International journal of developmental biology, Vol. 47, Issue 1, pp. 71-6, 2003 (PubMed).

Saada, Vogel, Hoefs et al.: "Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease." in: American journal of human genetics, Vol. 84, Issue 6, pp. 718-27, 2009 (PubMed).

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