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Nesprin3 antibody (Chromosome 14 Open Reading Frame 49) (AA 855-884)

Details for Product anti-C14orf49 Antibody No. ABIN953651, Supplier: Log in to see
Antigen
  • C14orf49
  • NET53
  • Nesp3
  • 4831426I19Rik
  • nesprin-3
Epitope
AA 855-884, C-Term
15
15
3
2
2
2
1
Reactivity
Human, Mouse (Murine)
29
13
Host
Rabbit
30
1
Clonality
Polyclonal
Conjugate
This Nesprin3 antibody is un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
28
22
14
4
3
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 855-884 amino acids from the C-terminal region of human SYNE3
Isotype Ig
Specificity This antibody reacts tp SYNE3.
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Affinity chromatography on Protein A
Alternative Name Nesprin-3 (C14orf49 Antibody Abstract)
Background Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.Synonyms: C14orf49
Molecular Weight 112216 Da
Gene ID 161176
NCBI Accession NP_689805
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Nesprin3 antibody (Chromosome 14 Open Reading Frame 49) (AA 855-884) (ABIN953651) SYNE3 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin ...
Western Blotting (WB) image for anti-Nesprin3 antibody (Chromosome 14 Open Reading Frame 49) (AA 855-884) (ABIN953651) SYNE3 Antibody (C-term) western blot analysis in mouse spleen cell line lysates (35µg...
Background publications Nery, Zeng, Niland et al.: "TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton." in: Journal of cell science, Vol. 121, Issue Pt 20, pp. 3476-86, 2008 (PubMed).

Stewart-Hutchinson, Hale, Wirtz et al.: "Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness." in: Experimental cell research, Vol. 314, Issue 8, pp. 1892-905, 2008 (PubMed).

Wilhelmsen, Litjens, Kuikman et al.: "Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin." in: The Journal of cell biology, Vol. 171, Issue 5, pp. 799-810, 2005 (PubMed).

Heilig, Eckenberg, Petit et al.: "The DNA sequence and analysis of human chromosome 14. ..." in: Nature, Vol. 421, Issue 6923, pp. 601-7, 2003 (PubMed).