CHRNA2 antibody (N-Term)

Catalog No. ABIN953677

Product Details anti-CHRNA2 Antibody

Target: CHRNA2 (Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2))

Binding Specificity: AA 49-77, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNA2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CHRNA1.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of human CHRNA2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CHRNA2

Target: CHRNA2 (Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2))

Alternative Name: Neuronal Acetylcholine Receptor Subunit alpha-2 (CHRNA2 Products)

Synonyms: CHRNA2 antibody, NACHRA2 antibody, chrna2 antibody, zgc:136717 antibody, ACHR antibody, Acra-2 antibody, Acra2 antibody, BC011490 antibody, cholinergic receptor nicotinic alpha 2 subunit antibody, cholinergic receptor, nicotinic, alpha 2a (neuronal) antibody, cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) antibody, neuronal acetylcholine receptor subunit alpha-2 antibody, neuronal acetylcholine receptor subunit alpha-4-like antibody, CHRNA2 antibody, chrna2a antibody, Chrna2 antibody, CpipJ_CPIJ002436 antibody, LOC100370261 antibody, Tsp_10995 antibody

Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.Synonyms: CHRNA2, Nicotinic acetylcholine receptor subunit alpha 2

Molecular Weight: 59765 Da

Gene ID: 1135

NCBI Accession: NP_000733