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serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody

Details for Product No. ABIN953686, Supplier: Login to see
Antigen
  • CG9453
  • Dmel\\CG9453
  • Serp2
  • Sp4
  • Spn4
  • Spn4A
  • dSerp2
  • sp4
  • spn4
  • SERPINI1
  • pi12
  • neuroserpin
  • AI837402
  • Ns
  • PI-12
  • PI12
  • Spi17
  • raPIT5a
Epitope
AA 26-53, N-Term
18
16
14
8
6
3
3
2
2
2
1
1
1
1
Reactivity
Human
98
48
27
2
1
1
1
1
1
Host
Rabbit
71
17
16
12
2
Clonality
Polyclonal
Conjugate
Un-conjugated
11
8
8
4
4
4
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
92
69
18
15
14
11
10
7
6
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of Human SERPINI1. Genename: SERPINI1
Isotype Ig
Specificity Recognizes SERPINI1 (N-term).
Purification Protein A column followed by peptide Affinity purification
Alternative Name Neuroserpin / SERPINI1 (SERPINI1 Antibody Abstract)
Background This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.Synonyms: PI-12, PI12, Peptidase inhibitor 12, Serpin I1
Gene ID 5274
NCBI Accession NP_001116224
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody (ABIN953686) Confocal Immunofluorescent analysis of SERPINI1 Antibody (N-term)Cat.-No AP53865PU-N ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody (ABIN953686) Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue...
Western Blotting (WB) image for anti-serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1) (AA 26-53), (N-Term) antibody (ABIN953686) Western blot analysis using SERPINI1 Antibody (N-term) Cat.-No AP53865PU-N in HepG2 c...
Background publications Takehara, Zhang, Yang et al.: "Refolding and polymerization pathways of neuroserpin." in: Journal of molecular biology, Vol. 403, Issue 5, pp. 751-62, 2010 (PubMed).

Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).

Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Davies, Miranda, Roussel et al.: "Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18202-9, 2009 (PubMed).

Rajaraman, Brenner, Butler et al.: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).