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Hypocretin (Orexin) Receptor 1 (HCRTR1) (AA 269-298), (Middle Region) antibody

Details for Product No. ABIN953936, Supplier: Log in to see
Antigen
  • HCRTR1
  • OX1R
  • Ox1r
  • Hctr1
  • hypocretin (orexin) receptor 1
  • orexin receptor 1
  • orexin receptor type 1-like
  • HCRTR1
  • LOC100352294
  • Hcrtr1
  • LOC443167
  • LOC100855896
Epitope
Middle Region, AA 269-298
16
14
11
11
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
79
37
32
6
6
5
5
4
3
3
2
1
Host
Rabbit
73
8
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
55
40
20
7
5
2
1
Options
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Immunogen KLH conjugated synthetic peptide between 269-298 amino acids from the Central region of Human Orexin receptor type 1 (Center) Genename: HCRTR1
Isotype Ig
Specificity This antibody recognizes Human Orexin receptor type 1 (Center)
Purification Protein A column, followed by peptide affinity purification
Alternative Name Orexin Receptor Type 1 (HCRTR1 Antibody Abstract)
Background The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.Synonyms: HCRTR1, Hypocretin receptor type 1, Ox1r
Molecular Weight 47536 Da
Gene ID 3061
NCBI Accession NP_001516
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Hypocretin (Orexin) Receptor 1 (HCRTR1) (AA 269-298), (Middle Region) antibody (ABIN953936) Western blot analysis of Orexin receptor type 1 Antibody (Center) in NCI-H292 cell li...
Background publications Peltonen, Akerman, Bart: "A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation." in: Biochimica et biophysica acta, Vol. 1803, Issue 10, pp. 1206-12, 2010 (PubMed).

Saus, Brunet, Armengol, Alonso, Crespo, Fernández-Aranda, Guitart, Martín-Santos, Menchón, Navinés, Soria, Torrens, Urretavizcaya, Vallès, Gratacòs, Estivill: "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients." in: Journal of psychiatric research, Vol. 44, Issue 14, pp. 971-8, 2010 (PubMed).

Turunen, Ekholm, Somerharju, Kukkonen: "Arachidonic acid release mediated by OX1 orexin receptors." in: British journal of pharmacology, Vol. 159, Issue 1, pp. 212-21, 2010 (PubMed).

Pinheiro, Bulik, Thornton, Sullivan, Root, Bloss, Berrettini, Schork, Kaye, Bergen, Magistretti, Brandt, Crawford, Crow, Fichter, Goldman, Halmi, Johnson, Kaplan, Keel, Klump, La Via, Mitchell, Strober, Rotondo, Treasure, Woodside: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

El Firar, Voisin, Rouyer-Fessard, Ostuni, Couvineau, Laburthe: "Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4069-80, 2009 (PubMed).