Hypocretin (Orexin) Receptor 2 (HCRTR2) (AA 274-304), (Middle Region) antibody

Details for Product No. ABIN953937
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Antigen
Synonyms LOC100229747, LOC443181, hcrtr, OX2R, mOX2aR, mOX2bR, mOXR2
Epitope
AA 274-304, Middle Region
(7), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(20), (3), (2), (2)
Host
Rabbit
(14), (4), (3)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB)
(18), (10), (5), (2), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN953937
357.50 $
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Immunogen KLH conjugated synthetic peptide between 274-304 amino acids from the Central region of Human Orexin receptor type 2 Genename: HCRTR2
Specificity This antibody recognizes Human and Mouse Orexin receptor type 2 (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name Orexin receptor type 2
Background The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.
Alternate names: HCRTR2, Hypocretin receptor type 2, Ox2r
Molecular Weight 50694 Da
Gene ID 3062
NCBI Accession NP_001517
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Chen, Randeva: "Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters." in: The Biochemical journal, Vol. 427, Issue 3, pp. 377-90, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

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