PABPN1 antibody (C-Term)

Catalog No. ABIN953974

Product Details anti-PABPN1 Antibody

Target: PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))

Binding Specificity: AA 269-298, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PABPN1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human PABPN1 (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 269-298 amino acids from the C-terminal region of human PABPN1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PABPN1

Target: PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))

Alternative Name: PABPN1 (PABPN1 Products)

Background: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails on the 3' ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of the coding region of this gene leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.Synonyms: Nuclear poly(A)-binding protein 1, PAB2, PABP-2, PABP2, Poly(A)-binding protein 2, Polyadenylate-binding nuclear protein 1, Polyadenylate-binding protein 2

Molecular Weight: 32749 Da

Gene ID: 8106

NCBI Accession: NP_004634