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PIK3AP1 antibody (phosphoinositide-3-Kinase Adaptor Protein 1) (C-Term)

Details for Product anti-PIK3AP1 Antibody No. ABIN954143, Supplier: Log in to see
Antigen
  • BCAP
  • RP11-34E5.3
  • 1810044J04Rik
  • phosphoinositide-3-kinase adaptor protein 1
  • PIK3AP1
  • Pik3ap1
Alternatives
anti-Human PIK3AP1 antibody for Flow Cytometry
Epitope
C-Term, AA 646-676
11
9
8
5
2
2
1
1
1
1
1
1
Reactivity
Human
84
22
17
4
2
Host
Rabbit
45
44
1
Clonality
Polyclonal
Conjugate
This PIK3AP1 antibody is un-conjugated
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
66
29
27
26
13
10
8
7
3
3
2
1
Options
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Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 646-676aa) of human PIK3AP1.
Isotype Ig
Specificity This antibody recognizes PIK3AP1 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Purified through a Protein A column followed by peptide affinity purification
Alternative Name PIK3AP1 (PIK3AP1 Antibody Abstract)
Background PIK3AP1 is involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. It couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. PIK3AP1 seems to have a complementary role with CD19 in PI3K activation (By similarity) and is may be involved in the survival of mature B cells via activation of REL (By similarity).Synonyms: B-cell adapter for phosphoinositide 3-kinase, BCAP, Phosphoinositide 3-kinase adapter protein 1
Gene ID 118788
NCBI Accession NP_689522
Pathways Activation of Innate immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-PIK3AP1 antibody (phosphoinositide-3-Kinase Adaptor Protein 1) (C-Term) (ABIN954143) Western blot analysis in A549 cell line lysates (35ug/lane) using PIK3AP1  Antibody  ...
Background publications Koutros, Schumacher, Hayes, Ma, Huang, Albanes, Canzian, Chanock, Crawford, Diver, Feigelson, Giovanucci, Haiman, Henderson, Hunter, Kaaks, Kolonel, Kraft, Le Marchand, Riboli, Siddiq, Stampfer, Stram, Thomas, Travis, Thun, Yeager, Berndt: "Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer." in: Cancer research, Vol. 70, Issue 6, pp. 2389-96, 2010 (PubMed).

Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Maruoka, Suzuki, Kawata, Yoshida, Hirao, Sato, Goff, Takeya, Tani, Shishido: "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases." in: FEBS letters, Vol. 579, Issue 14, pp. 2986-90, 2005 (PubMed).

Grupe, Li, Rowland, Nowotny, Hinrichs, Smemo, Kauwe, Maxwell, Cherny, Doil, Tacey, van Luchene, Myers, Wavrant-De Vrièze, Kaleem, Hollingworth, Jehu, Foy, Archer, Hamilton, Holmans, Morris, Catanese et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ..." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Okada, Maeda, Iwamatsu, Gotoh, Kurosaki: "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation." in: Immunity, Vol. 13, Issue 6, pp. 817-27, 2001 (PubMed).