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Profilin 2 (PFN2) (AA 109-139), (C-Term) antibody

Details for Product No. ABIN954303, Supplier: Log in to see
Antigen
  • d3s1319e
  • D3S1319E
  • F17A13.170
  • F17A13_170
  • PFL
  • pfl
  • Pfn
  • PFN2
  • PRF2
  • PRO2
  • PROFILIN
  • Profilin-2
  • profilin-2
  • PROFILIN 2
  • Profilin2
  • profilin 2
  • XProfilin2
Epitope
C-Term, AA 109-139
20
15
10
5
2
2
2
2
2
2
2
1
1
1
Reactivity
Human
71
22
22
2
2
Host
Rabbit
56
13
2
Clonality
Polyclonal
Conjugate
Un-conjugated
6
5
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
55
31
11
11
7
1
1
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 109-139 amino acids from the C-terminal region of Human Profilin 2 (PFN2)
Isotype Ig
Specificity This antibody recognizes Human Profilin-2 / PFN2 (C-term).
Purification Protein A column, followed by peptide affinity purification
Background The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this geneSynonyms: Profilin II, Profilin-2
Molecular Weight 15046 Da
Gene ID 5217
NCBI Accession NP_002619
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Profilin 2 (PFN2) (AA 109-139), (C-Term) antibody (ABIN954303) Western blot analysis of PFN2 Antibody (C-term) in Y79 cell line lysates (35ug/lane)....
Background publications Shao, Welch, Diprospero, Diamond: "Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation." in: Molecular and cellular biology, Vol. 28, Issue 17, pp. 5196-208, 2008

Xu, Shi, Matsumoto, Noda, Kitayama: "Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II." in: Cellular signalling, Vol. 19, Issue 7, pp. 1575-82, 2007

Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007

Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: "A human protein-protein interaction network: a resource for annotating the proteome. ..." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005

Callan: "The organization of genetic units in chromosomes." in: Journal of cell science, Vol. 2, Issue 1, pp. 1-7, 1970