PROC antibody

Catalog No. ABIN954315

Product Details anti-PROC Antibody

Target: PROC (Vitamin K-dependent protein C (PROC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PROC antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody is specific for Human Protein C/APC in the presence of 5-10 mM CaCl2.

Purification: Affinity chromatography on Protein G

Immunogen: Human Protein C purified from the supernatant of thrombin activated platelets.

Clone: CaC-11

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PROC

Target: PROC (Vitamin K-dependent protein C (PROC))

Alternative Name: Protein C / PROC (PROC Products)

Synonyms: proc antibody, si:ch1073-188c16.3 antibody, zgc:63987 antibody, PROC antibody, APC antibody, PC antibody, PROC1 antibody, THPH3 antibody, THPH4 antibody, proc1 antibody, MGC64425 antibody, PA antibody, protein C, inactivator of coagulation factors Va and VIIIa antibody, protein C (inactivator of coagulation factors Va and VIIIa), a antibody, protein C (inactivator of coagulation factors Va and VIIIa) antibody, protein C, inactivator of coagulation factors Va and VIIIa S homeolog antibody, vitamin K-dependent protein C antibody, prosaposin antibody, protein C antibody, proline rich protein HaeIII subfamily 1 antibody, PROC antibody, proca antibody, proc.S antibody, proc antibody, CpipJ_CPIJ000393 antibody, CpipJ_CPIJ002754 antibody, CpipJ_CPIJ003717 antibody, CpipJ_CPIJ003718 antibody, CpipJ_CPIJ014440 antibody, CpipJ_CPIJ018032 antibody, CpipJ_CPIJ018737 antibody, PSAP antibody, Proc antibody, PRH1 antibody

Target Type: Viral Protein

Background: Protein C (PC) is a major physiological anticoagulant, and an important regulator of the blood coagulation system. PC is a vitamin K dependent serine protease enzyme that is activated by thrombin. The anticoagulant PC is converted to activated protein C (APC) by the thrombomodulin (TM) - thrombin complex on the phospholipid surface of endothelial cells, monocytes and platelets. APC degrades coagulation Factors Va and VIIIa rendering these factors inactive. APC provides physiologic antithrombotic activity and exhibits both anti-inflammatory and anti-apoptotic activity. Treatment with APC has been shown to improve the clinical outcome of patients with sepsis.Synonyms: Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Inactivator of coagulation factors Va and VIIIa, PROC1, Vitamin K-dependent protein C

Gene ID: 5624

NCBI Accession: NP_000303

UniProt: P04070