Prothrombin antibody (Coagulation Factor II (thrombin)) (Biotin)

Details for Product anti-F2 Antibody No. ABIN954322, Supplier: Log in to see
Antigen
  • zgc:66319
  • wu:fb57c10
  • wu:fd42e09
  • wu:fd59d01
  • Cf-2
  • Cf2
  • FII
  • thrombin
  • PT
  • RPRGL2
  • THPH1
  • prothrombin
  • AA959438
  • AI255193
  • AI327365
  • C1sa
  • HTRA
  • HTRA1
  • F2
  • coagulation factor II (thrombin)
  • cell division cycle 34
  • chymase 1, mast cell
  • coagulation factor II
  • complement component 1, s subcomponent
  • HtrA serine peptidase 1
  • HtrA serine peptidase 2
  • melanoma antigen family B, 17-like
  • prothrombin-like
  • serine protease
  • THROMBIN protein
  • f2
  • F2
  • Cdc34
  • CMA1
  • C1s
  • Htra1
  • HTRA2
  • LOC783975
  • LOC100856539
  • HTRA
  • THROMBIN
Alternatives
anti-Human Prothrombin antibody for Blocking Antibody
Reactivity
Human
147
68
36
8
7
3
2
2
2
2
1
Host
Mouse
82
62
56
8
5
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This Prothrombin antibody is conjugated to Biotin
22
12
12
5
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
140
108
39
20
16
15
15
14
14
13
11
8
6
3
3
2
1
1
1
1
1
1
Options
Supplier
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Immunogen Human Prothrombin (CaPro-20) purified from plasma.
Clone CaPro-20
Isotype IgG1
Specificity This antibody is specific for Human Prothrombin (CaPro-20).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Alternative Name Prothrombin (F2) (F2 Antibody Abstract)
Background Prothrombin (Factor 2 in the coagulation cascade) is proteolytically cleaved at two sites by Factor Xa to form thrombin (Factor IIa) in an important step of the coagulation cascade which ultimately results in the stemming of blood loss. Thrombin being the single most important constituent of the coagulation cascade in terms of its feedback activation roles. Prothrombin also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in Prothrombin lead to various forms of thrombosis and dysprothrombinemia. Prothrombin is a 72 kDa blood clotting glycoprotein formed by and stored in the Liver. Prothrombin is present in the blood plasma and is converted to the key blood clotting agent thrombin, when blood vessels are damaged. Factor VII, another important haemostasis protein can be converted to VIIa by Factor IXa or Thrombin.Synonyms: Coagulation factor II
Gene ID 2147
NCBI Accession NP_000497
UniProt P00734
Pathways Complement System, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Bharadwaj, Iino, Kontoyianni, Smith, Foster, Kisiel: "Factor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity." in: The Journal of biological chemistry, Vol. 271, Issue 48, pp. 30685-91, 1997 (PubMed).

Kazama, Pastuszyn, Wildgoose, Hamamoto, Kisiel: "Isolation and characterization of proteolytic fragments of human factor VIIa which inhibit the tissue factor-enhanced amidolytic activity of factor VIIa." in: The Journal of biological chemistry, Vol. 268, Issue 22, pp. 16231-40, 1993 (PubMed).

Yamamoto, Nakagaki, Kisiel: "Tissue factor-dependent autoactivation of human blood coagulation factor VII." in: The Journal of biological chemistry, Vol. 267, Issue 27, pp. 19089-94, 1992 (PubMed).