PSMB10 antibody (C-Term)

Catalog No. ABIN954355

Product Details anti-PSMB10 Antibody

Target: PSMB10 (Proteasome (Prosome, Macropain) Subunit, beta Type 10 (PSMB10))

Binding Specificity: AA 213-242, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMB10 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human PSMB10 (C-term).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 213-242 amino acids from the C-terminal region of Human PSMB10

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PSMB10

Target: PSMB10 (Proteasome (Prosome, Macropain) Subunit, beta Type 10 (PSMB10))

Alternative Name: PSMB10 (PSMB10 Products)

Synonyms: Mecl-1 antibody, Mecl1 antibody, LMP10 antibody, MECL1 antibody, beta2i antibody, proteasome (prosome, macropain) subunit, beta type 10 antibody, proteasome subunit beta 10 antibody, Psmb10 antibody, PSMB10 antibody

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.Synonyms: EC=3.4.25.1, MECL1, Macropain subunit MECl-1, Multicatalytic endopeptidase complex subunit MECl-1, PSMB10, Proteasome MECl-1, Proteasome subunit beta type-10, Proteasome subunit beta-2i

Molecular Weight: 28936 Da

Gene ID: 5699

NCBI Accession: NP_002792

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA