Prostate Tumor Overexpressed 1 (PTOV1) (N-Term), (AA 28-56) antibody

Details for Product No. ABIN954371
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Synonyms 1110030G05Rik, AU041779, Gcap3, ACID2, PTOV-1
N-Term, AA 28-56
(17), (14), (1)
Human, Mouse (Murine)
(31), (15), (14), (2)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(22), (13), (10), (10), (4), (3)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN954371
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Immunogen Synthetic peptide - KLH conjugated corresponding to the N-terminal region between 28-56 amino acids of Human PTOV1. Genename: PTOV1.
Isotype Ig
Specificity This antibody recognizes Human and Mouse PTOC1 at N-term.
Purification Protein A column, followed by peptide affinity purification
Alternative Name PTOV1
Background PTOV1 may activate transcription. It is Required for nuclear translocation of FLOT1 and promotes cell proliferation.Synonyms: ACID2, Activator interaction domain-containing protein 2, PTOV-1, Prostate tumor-overexpressed gene 1 protein
Molecular Weight 46869 Da
Gene ID 53635
NCBI Accession NP_059128
Research Area Cancer, Cell Cycle, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Morote, Fernández, Alaña et al.: "PTOV1 expression predicts prostate cancer in men with isolated high-grade prostatic intraepithelial neoplasia in needle biopsy." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 9, pp. 2617-22, 2008 (PubMed).

Santamaría, Castellanos, Gómez et al.: "PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1900-11, 2005 (PubMed).

Mittler, Stühler, Santolin et al.: "A novel docking site on Mediator is critical for activation by VP16 in mammalian cells." in: The EMBO journal, Vol. 22, Issue 24, pp. 6494-504, 2003 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Santamaría, Fernández, Farré et al.: "PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle." in: The American journal of pathology, Vol. 162, Issue 3, pp. 897-905, 2003 (PubMed).

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