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Pseudouridylate Synthase 1 (PUS1) (AA 329-358), (C-Term) antibody

Details for Product No. ABIN954388, Supplier: Log in to see
Antigen
  • PUS1
  • A730013B20Rik
  • MPUS1
  • mPus1p
  • MLASA1
Epitope
AA 329-358, C-Term
17
15
7
5
5
2
1
1
Reactivity
Human
36
10
6
Host
Rabbit
36
5
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
38
21
14
6
5
4
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 329-358 amino acids from the C-terminal region of Human PUS1
Isotype Ig
Specificity This antibody recognizes Humann PUS1 (C-term).
Purification Affinity Chromatography on Protein A
Alternative Name PUS1 (PUS1 Antibody Abstract)
Background This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variantsSynonyms: MGC11268, MLASA1, PP8985, Pseudouridylate synthase 1, tRNA pseudouridine synthase A mitochondrial, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I
Molecular Weight 47470 Da
Gene ID 80324
NCBI Accession NP_001002019
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Pseudouridylate Synthase 1 (PUS1) (AA 329-358), (C-Term) antibody (ABIN954388) Formalin fixed, paraffin embedded human skeletal muscle stained with PUS1 Antibody (C...
Western Blotting (WB) image for anti-Pseudouridylate Synthase 1 (PUS1) (AA 329-358), (C-Term) antibody (ABIN954388) Western blot analysis of PUS1 Antibody (C-term) in NCI-H460 cell line lysates (35ug/l...
Background publications Bergmann, Campagna, McLoughlin et al.: "Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations." in: Pediatric blood & cancer, Vol. 54, Issue 2, pp. 273-8, 2009 (PubMed).

Demling: "Burns: what are the pharmacological treatment options?" in: Expert opinion on pharmacotherapy, Vol. 9, Issue 11, pp. 1895-908, 2008 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Sugiyama, Masuda, Shinoda et al.: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).