Importin 8 antibody (C-Term)

Catalog No. ABIN954450

Product Details anti-Importin 8 Antibody

Target: Importin 8 (IPO8)

Binding Specificity: C-Term

Reactivity: Human, Dog, Cow, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This Importin 8 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: C-SAFNFGTVPS NN

Specificity: This antibody is expected to recognise isoform 1 (NP_006381.2) and isoform 2 (NP_001177924.1).

Cross-Reactivity (Details): Species reactivity (expected):Dog, Pig, Cow.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C-Terminus of the protein sequence according to NP_006381.2, NP_001177924.1. Genename: IPO8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Importin 8

Target: Importin 8 (IPO8)

Alternative Name: RanBP8 / Importin-8 (IPO8 Products)

Synonyms: IPO8 antibody, si:ch211-116i17.1 antibody, RANBP8 antibody, 6230418K12Rik antibody, Abcc10 antibody, C130009K11Rik antibody, MRP7 antibody, OM-1 antibody, Om1 antibody, Ranbp8 antibody, importin 8 antibody, IPO8 antibody, ipo8 antibody, Ipo8 antibody

Background: Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.Synonyms: IMP8, IPO8, RAN binding protein 8

Gene ID: 10526

NCBI Accession: NP_006381