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Ring Finger Protein 34 (RNF34) (AA 282-311), (C-Term) antibody

Details for Product No. ABIN954520, Supplier: Log in to see
Antigen
  • rnf34
  • AW061037
  • AW536122
  • BC004042
  • C88279
  • RIFF
  • CARP-1
  • CARP1
  • RFI
  • RIF
  • hRFI
  • Momo
Epitope
C-Term, AA 282-311
23
18
16
14
14
3
2
2
Reactivity
Human
81
20
18
15
13
2
2
2
2
2
2
1
1
1
Host
Rabbit
48
33
3
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
4
3
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
57
48
20
10
7
5
2
Supplier
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Immunogen KLH conjugated synthetic peptide between 282-311 amino acids from the C-terminal region of human RNF34
Isotype Ig
Specificity This antibody reacts to RNF34.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name RFI / RNF34 (RNF34 Antibody Abstract)
Background The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.Synonyms: CARP-1, CARP1, Caspases-8 and -10-associated RING finger protein 1, E3 ubiquitin-protein ligase RNF34, FYVE-RING finger protein Momo, Human RING finger homologous to inhibitor of apoptosis protein, RIFF
Molecular Weight 41641 Da
Gene ID 80196
NCBI Accession NP_079402
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Ring Finger Protein 34 (RNF34) (AA 282-311), (C-Term) antibody (ABIN954520) RNF34 Antibody (C-term) western blot analysis in Hela cell line lysates (35µg/lane).T...
Background publications Grunda, Fiveash, Palmer et al.: "Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 10, pp. 2890-8, 2010 (PubMed).

Yang, Dicker, Chen et al.: "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 5, pp. 670-82, 2008 (PubMed).

Yang, Rozan, McDonald et al.: "CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 3273-81, 2007 (PubMed).

Konishi, Sasaki, Watanabe et al.: "Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells." in: Molecular cancer therapeutics, Vol. 4, Issue 5, pp. 743-50, 2005 (PubMed).

Sasaki, Watanabe, Konishi et al.: "Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence." in: Journal of experimental & clinical cancer research : CR, Vol. 23, Issue 3, pp. 507-12, 2004 (PubMed).