S100A8 antibody (S100 Calcium Binding Protein A8) (FITC)

Details for Product anti-S100A8 Antibody No. ABIN954653, Supplier: Log in to see
Antigen
  • EWWD
  • MRP8
  • WW
  • 60B8AG
  • CAGA
  • CFAG
  • CGLA
  • CP-10
  • L1Ag
  • MA387
  • MIF
  • NIF
  • P8
  • Mrp8
  • S100A8
  • 60B8Ag
  • AI323541
  • B8Ag
  • CFAg
  • Caga
  • p8
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 11
  • S100 calcium binding protein A8
  • S100 calcium binding protein A8 (calgranulin A)
  • ABCC11
  • S100A8
  • S100a8
Alternatives
anti-Human S100A8 antibody for Immunohistochemistry
Reactivity
Human
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Host
Mouse
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1
Clonality (Clone)
Monoclonal ()
Conjugate
This S100A8 antibody is conjugated to FITC
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11
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Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen Purified granulocyte antigen of Human origin.
Clone CF-145
Isotype IgG2b
Specificity This antibody detects Calgranulin A (S100A8).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Protein G Chromatography of Ascitic fluid.
Alternative Name S100A8 / Calgranulin-A / MRP8 (S100A8 Antibody Abstract)
Background Calgranulin A, also known as MRP-8 and S100A8 is a member of the S100 family of proteins containing 2 EF hand (alpha helix, turn, alpha helix structure) calcium binding motifs. S100 proteins are localized in the cytoplasm and /or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. MRP-8 (S100A8) forms a heterodimeric complex with Calgranulin B, (MRP-14, S100A9) in the cytosol of monocyte and neutrophil cell types circulating in peripheral blood. Calgranulin A is found in elevated levels in the serum of cystic fibrosis cases and is also expressed in the skin of patients with psoriasis, eczematous dermatitis and squamous cell carcinoma.Synonyms: CAGA, CFAG, Calprotectin L1L subunit, Cystic fibrosis antigen, Leukocyte L1 complex light chain, MRP-8, Migration inhibitory factor-related protein 8, S100 calcium-binding protein A8, S100-A8, Urinary stone protein band A
Gene ID 6279
NCBI Accession NP_002955
UniProt P05109
Research Area Cell Cycle
Pathways Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (IHC) image for anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC) (ABIN954653) anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC)
Flow Cytometry (FACS) image for anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC) (ABIN954653) anti-S100 Calcium Binding Protein A8 (S100A8) antibody (FITC) (Image 2)
Background publications Thacher, Nagpal, Klein, Arefieg, Krasinski, DiSepio, Agarwal, Johnson, Eckert, Chandraratna: "Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 10, Issue 4, pp. 255-62, 1999 (PubMed).

Nagpal, Thacher, Patel, Friant, Malhotra, Shafer, Krasinski, Asano, Teng, Duvic, Chandraratna: "Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 7, Issue 12, pp. 1783-91, 1997 (PubMed).

Klein, Pino, Johnson, Davies, Nagpal, Thacher, Krasinski, Chandraratna: "Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22692-6, 1996 (PubMed).

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