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Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2) (AA 258-288), (Middle Region) antibody

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Synonyms CEGB1, CEGF1, CEGP1, 4932442O19Rik, Cegf1, Cegp1, RGD1563998, Scube2-ps1, wu:fc27f08, you
AA 258-288, Middle Region
(17), (15), (13), (9), (6), (2), (1), (1), (1)
(37), (9), (2), (2), (1)
(2), (2), (2), (2), (2), (2), (1)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(35), (27), (17), (14), (13), (6), (3), (2), (1)
Pubmed 5 references available
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Quantity 0.4 mL
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Immunogen KLH conjugated synthetic peptide between 258-288 amino acids from the Central region of Human SCUBE2. Genename: SCUBE2
Isotype Ig
Specificity Recognizes SCUBE2 Human (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name SCUBE2
Background SCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.Synonyms: CEGP1, Signal peptide CUB and EGF-like domain-containing protein 2
Molecular Weight 109966 Da
Gene ID 57758
NCBI Accession NP_001164161
Research Area Stem Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2) (AA 258-288), (Middle Region) antibody (ABIN954694) Confocal Immunofluorescent analysis of SCUBE2 Antibody (Center) Cat.-No AP53818PU-N w...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2) (AA 258-288), (Middle Region) antibody (ABIN954694) Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human breast carci...
Western Blotting (WB) image for anti-Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2) (AA 258-288), (Middle Region) antibody (ABIN954694) Western blot analysis of SCUBE2 Antibody (Center) Cat.-No AP53818PU-N in MDA-MB453,ZR...
Background publications Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).

Tsai, Cheng, Lin et al.: "Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans." in: The Biochemical journal, Vol. 422, Issue 1, pp. 119-28, 2009 (PubMed).

Shen, Vermeulen, Rajaraman et al.: "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China." in: Environmental and molecular mutagenesis, Vol. 50, Issue 4, pp. 285-90, 2009 (PubMed).

Hanna, Kruskal, Ezekowitz et al.: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).

Catalog No. ABIN954694
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