Signal Peptide, CUB Domain, EGF-Like 2 (SCUBE2) (AA 258-288), (Middle Region) antibody

Details for Product No. ABIN954694
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Antigen
Synonyms CEGB1, CEGF1, CEGP1, 4932442O19Rik, Cegf1, Cegp1, RGD1563998, Scube2-ps1, wu:fc27f08, you
Epitope
AA 258-288, Middle Region
(8), (7), (6), (4), (3), (2), (1)
Reactivity
Human
(34), (21), (13), (12), (12), (3)
Host
Rabbit
(37)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(27), (18), (16), (10), (8), (7), (5)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN954694
357.50 $
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Immunogen KLH conjugated synthetic peptide between 258-288 amino acids from the Central region of Human SCUBE2. Genename: SCUBE2
Specificity Recognizes SCUBE2 Human (Center).
Purification Protein A column, followed by peptide affinity purification
Alternative Name SCUBE2
Background SCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.
Alternate names: CEGP1, Signal peptide CUB and EGF-like domain-containing protein 2
Molecular Weight 109966 Da
Gene ID 57758
NCBI Accession NP_001164161
Research Area Stem Cells
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Hanna, Kruskal, Ezekowitz et al.: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).

Shen, Vermeulen, Rajaraman et al.: "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China." in: Environmental and molecular mutagenesis, Vol. 50, Issue 4, pp. 285-90, 2009 (PubMed).

Tsai, Cheng, Lin et al.: "Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans." in: The Biochemical journal, Vol. 422, Issue 1, pp. 119-28, 2009 (PubMed).

Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).

Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

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