TAFI48 antibody, mTAFI48 antibody, MGC:17061 antibody, RAFI48 antibody, SL1 antibody, TATA-box binding protein associated factor, RNA polymerase I, A antibody, TATA-box binding protein associated factor, RNA polymerase I subunit A antibody, Taf1a antibody, TAF1A antibody
Background
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.Synonyms: TAFI48, TATA box-binding protein-associated factor RNA polymerase I subunit A, TBP-associated factor 1A, TBP-associated factor RNA polymerase I 48 kDa, Transcription factor SL1