TBC1D22A antibody (TBC1 Domain Family, Member 22A) (C-Term)

Details for Product anti-TBC1D22A Antibody No. ABIN955093, Supplier: Log in to see
Antigen
  • C22orf4
  • HSC79E021
  • BC023106
  • D15Ertd781e
  • RGD1306588
  • TBC1 domain family, member 22A
  • TBC1 domain family, member 22a
  • TBC1D22A
  • Tbc1d22a
Epitope
C-Term, AA 329-358
10
10
8
4
2
1
1
1
1
Reactivity
Human
35
8
7
4
4
4
3
3
3
3
2
1
1
1
1
Host
Rabbit
35
Clonality
Polyclonal
Conjugate
This TBC1D22A antibody is un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
31
19
18
6
1
1
Options
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Immunogen KLH conjugated synthetic peptide between 329-358 amino acids from the C-terminal region of human PUS1
Isotype Ig
Specificity This antibody reacts to PUS1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Alternative Name TBC1D22A (TBC1D22A Antibody Abstract)
Background This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.Synonyms: C22orf4, TBC1 domain family member 22A
Molecular Weight 59121 Da
Gene ID 25771
NCBI Accession NP_055161
Research Area Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TBC1D22A antibody (TBC1 Domain Family, Member 22A) (C-Term) (ABIN955093) PUS1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin e...
Western Blotting (WB) image for anti-TBC1D22A antibody (TBC1 Domain Family, Member 22A) (C-Term) (ABIN955093) PUS1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35µg/lane...
Background publications Bergmann, Campagna, McLoughlin, Agarwal, Fleming, Bottomley, Neufeld: "Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations." in: Pediatric blood & cancer, Vol. 54, Issue 2, pp. 273-8, 2009 (PubMed).

Demling: "Burns: what are the pharmacological treatment options?" in: Expert opinion on pharmacotherapy, Vol. 9, Issue 11, pp. 1895-908, 2008 (PubMed).

Fernandez-Vizarra, Berardinelli, Valente, Tiranti, Zeviani: "Nonsense mutation in pseudouridylate synthase 1 (PUS1) in two brothers affected by myopathy, lactic acidosis and sideroblastic anaemia (MLASA)." in: Journal of medical genetics, Vol. 44, Issue 3, pp. 173-80, 2007 (PubMed).

Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: "Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 6, pp. 1103-9, 2007 (PubMed).

Rikova, Guo, Zeng, Possemato, Yu, Haack, Nardone, Lee, Reeves, Li, Hu, Tan, Stokes, Sullivan, Mitchell, Wetzel, Macneill, Ren, Yuan, Bakalarski, Villen, Kornhauser, Smith, Li, Zhou, Gygi, Gu et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. ..." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).