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TBC1D3E (AA 497-527), (C-Term) antibody

Details for Product No. ABIN955097, Supplier: Log in to see
Antigen
Epitope
C-Term, AA 497-527
11
7
3
Reactivity
Human
12
Host
Rabbit
12
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
11
8
Supplier
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Immunogen KLH conjugated synthetic peptide between 497-527 amino acids from the C-terminal region of human TBC1D3E
Isotype Ig
Specificity This antibody reacts to TBC1D3E.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Affinity chromatography on Protein A
Background BC1D3E acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).Synonyms: TBC1 domain family member 3E/3F
Molecular Weight 62199 Da
Gene ID 84218
NCBI Accession NP_115634
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-TBC1D3E (AA 497-527), (C-Term) antibody (ABIN955097) TBC1D3E Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35µg/l...
Background publications Alkan, Kidd, Marques-Bonet, Aksay, Antonacci, Hormozdiari, Kitzman, Baker, Malig, Mutlu, Sahinalp, Gibbs, Eichler: "Personalized copy number and segmental duplication maps using next-generation sequencing." in: Nature genetics, Vol. 41, Issue 10, pp. 1061-7, 2009

Wainszelbaum, Charron, Kong, Kirkpatrick, Srikanth, Barbieri, Gygi, Stahl: "The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking." in: The Journal of biological chemistry, Vol. 283, Issue 19, pp. 13233-42, 2008

Hodzic, Kong, Wainszelbaum, Charron, Su, Stahl: "TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12." in: Genomics, Vol. 88, Issue 6, pp. 731-6, 2006

Zody, Garber, Adams, Sharpe, Harrow, Lupski, Nicholson, Searle, Wilming, Young, Abouelleil, Allen, Bi, Bloom, Borowsky, Bugalter, Butler, Chang, Chen, Cook, Corum, Cuomo, de Jong, DeCaprio, Dewar et al.: "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. ..." in: Nature, Vol. 440, Issue 7087, pp. 1045-9, 2006

Paulding, Ruvolo, Haber: "The Tre2 (USP6) oncogene is a hominoid-specific gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2507-11, 2003