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Transcription Factor A, Mitochondrial (TFAM) (AA 223-254), (C-Term) antibody

Details for Product No. ABIN955168, Supplier: Login to see
Antigen
  • tcf6
  • mttf1
  • mttfa
  • tcf6l1
  • tcf6l2
  • tcf6l3
  • mttfa-A
  • xl-mtTFA
  • MGC153358
  • zgc:153358
  • MTTF1
  • MTTFA
  • TCF6
  • TCF6L1
  • TCF6L2
  • TCF6L3
  • AI661103
  • Hmgts
  • mtTFA
  • tsHMG
  • Mttfa
Epitope
AA 223-254, C-Term
24
15
10
7
6
6
5
5
3
3
3
3
2
2
1
1
1
1
1
Reactivity
Human
94
30
30
2
1
1
Host
Rabbit
115
2
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
77
46
45
33
21
18
16
11
6
6
4
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 223-254 amino acids from the C-terminal region of human TFAM
Isotype Ig
Specificity This antibody detects TFAM (C-term).
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A column followed by peptide affinity purification
Alternative Name TFAM / TCF6 (TFAM Antibody Abstract)
Background This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.Synonyms: Mitochondrial transcription factor 1, MtTF1, TCF-6, TCF6L2, Transcription factor 6, Transcription factor 6-like 2, mitochondrial Transcription factor A
Gene ID 7019
NCBI Accession NP_003192
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Supplier Images
Flow Cytometry (FACS) image for anti-Transcription Factor A, Mitochondrial (TFAM) (AA 223-254), (C-Term) antibody (ABIN955168) TFAM Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compa...
Immunofluorescence (IF) image for anti-Transcription Factor A, Mitochondrial (TFAM) (AA 223-254), (C-Term) antibody (ABIN955168) Confocal immunofluorescent analysis of TFAM Antibody (C-term) with Hela cell followed...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Transcription Factor A, Mitochondrial (TFAM) (AA 223-254), (C-Term) antibody (ABIN955168) TFAM antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin e...
Western Blotting (WB) image for anti-Transcription Factor A, Mitochondrial (TFAM) (AA 223-254), (C-Term) antibody (ABIN955168) TFAM Antibody (C-term) western blot analysis in K562 cell line lysates (35 µg/lane). ...
Background publications Corneveaux, Myers, Allen et al.: "Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals." in: Human molecular genetics, Vol. 19, Issue 16, pp. 3295-301, 2010 (PubMed).

Akhmetov, Popov, Missina et al.: "[Association of the mitochondrial transcription factor (TFAM) gene polymorphism with physical performance of athletes]." in: Fiziologiia cheloveka, Vol. 36, Issue 2, pp. 121-5, 2010 (PubMed).