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Transferrin Receptor 2 antibody (C-Term)

TFR2 Reactivity: Human WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN955173
  • Target See all Transferrin Receptor 2 (TFR2) Antibodies
    Transferrin Receptor 2 (TFR2)
    Binding Specificity
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 673-703, C-Term
    Reactivity
    • 34
    • 10
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 38
    • 5
    Rabbit
    Clonality
    • 30
    • 13
    Polyclonal
    Conjugate
    • 23
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Transferrin Receptor 2 antibody is un-conjugated
    Application
    • 31
    • 21
    • 15
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects Human TFR2 (C-term). Other species not tested.
    Purification
    Protein A column followed by peptide affinity purification
    Immunogen
    KLH conjugated synthetic peptide between 673-703 amino acids from the C-terminal region of human TFR2
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TFR2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 0.09 % (W/V) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
  • Target
    Transferrin Receptor 2 (TFR2)
    Alternative Name
    TFR2 (TFR2 Products)
    Synonyms
    TFR2 antibody, Trfr2 antibody, HFE3 antibody, TFRC2 antibody, zgc:123043 antibody, transferrin receptor 2 antibody, TFR2 antibody, Tfr2 antibody, tfr2 antibody
    Background
    This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. Function: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Cellular Location: Cell membrane, Single-pass type II membrane protein. Tissue Location: Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.Synonyms: Transferrin receptor protein 2
    Molecular Weight
    88755 Da (Calculated)
    Gene ID
    7036
    NCBI Accession
    NP_001193784
    Pathways
    Transition Metal Ion Homeostasis
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