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Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila) (TLE2) (C-Term), (AA 636-665) antibody

Details for Product No. ABIN955231
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Antigen
Synonyms TLE2, ESG, ESG2, GRG2, Grg2, mKIAA4188
Epitope
C-Term, AA 636-665
(7), (6), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(26), (7), (1)
Host
Rabbit
(28), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(31), (20), (3), (2), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN955231
357.50 $
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Immunogen KLH conjugated synthetic peptide between 636-665 amino acids from the C-terminal region of human TLE2
Specificity This antibody detects TLE2 (C-term).
Purification Protein A column followed by peptide affinity purification
Alternative Name TLE2
Background TLE2 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Alternate names: GRG2, TLE2, Transducin-like enhancer protein 2
Gene ID 7089
NCBI Accession NP_001138233
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Howell, Whitfield: "Synthesis and secretion of growth hormone in the rat anterior pituitary. I. The intracellular pathway, its time course and energy requirements." in: Journal of cell science, Vol. 12, Issue 1, pp. 1-21, 1973 (PubMed).

Grbavec, Lo, Liu et al.: "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms." in: The Biochemical journal, Vol. 337 ( Pt 1), pp. 13-7, 1999 (PubMed).

Higa, Wu, Ye et al.: "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation." in: Nature cell biology, Vol. 8, Issue 11, pp. 1277-83, 2006 (PubMed).

He, Liu, Liang et al.: "Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus." in: Journal of virology, Vol. 84, Issue 4, pp. 2047-62, 2010 (PubMed).

Validation Images
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